2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-115433R
    α-Muricholic acid (Standard) 2393-58-0
    α-Muricholic acid (Standard) is the analytical standard of α-Muricholic acid. This product is intended for research and analytical applications. α-Muricholic acid is the most abundant primary bile acid in rodents.
    α-Muricholic acid (Standard)
  • HY-115433S
    α-Muricholic acid-d5 98%
    α-Muricholic acid-d5 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents.
    α-Muricholic acid-d5
  • HY-115708S
    C22 Phytoceramide-d3 (t18:0/22:0) 2011762-87-9 98%
    C22 Phytoceramide-d3 (t18:0/22:0) is a deuterated labeled C22 Phytoceramide (t18:0/22:0). C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels. It has also been found in primary human astrocytes.
    C22 Phytoceramide-d3 (t18:0/22:0)
  • HY-116392E
    D-threo-PDMP 109836-82-0 98%
    D-threo-PDMP is a potent glucoceramide synthase (GCS) inhibitor, which reduces the glycosphingolipids on the cell surface by inhibiting glycosylation, reduces the total length of the axon plexus and the number of axon branch points, and inhibits neurite growth.
    D-threo-PDMP
  • HY-116739R
    13(E)-Docosenoic acid (Standard) 506-33-2
    2,4-D methyl ester (Standard) is the analytical standard of 2,4-D methyl ester. This product is intended for research and analytical applications. 2,4-D methyl ester is a bioactive compound with the activity of promoting the accumulation of nutritional and medicinal components. 2,4-D methyl ester can be used to enhance the production of bioactive components in Cordyceps militaris. 2,4-D methyl ester showed an inductive effect on bioactive components at specific concentrations. The application of 2,4-D methyl ester provides an effective strategy to improve the fruit quality of Cordyceps militaris. 2,4-D methyl ester, as a biostimulant, can induce dose-dependent responses in different components.
    13(E)-Docosenoic acid (Standard)
  • HY-117103A
    AMG131 benzenesulfonate 849738-78-9 98%
    AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus.
    AMG131 benzenesulfonate
  • HY-117275A
    Meclofenamic acid sodium hydrate 67254-91-5 98%
    Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively.
    Meclofenamic acid sodium hydrate
  • HY-117275R
    Meclofenamic acid (Standard) 644-62-2
    Meclofenamic acid (Standard) is the analytical standard of Meclofenamic acid. This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively.
    Meclofenamic acid (Standard)
  • HY-117727S
    Leriglitazone-d4 1188263-49-1 98%
    Leriglitazone-d4 (MIN-102-d4; Hydroxypioglitazone-d4) is deuterium labeled Leriglitazone. Leriglitazone is an orally active and a BBB-penetrable PPARγ agonist with an EC50 of 9 μM. Leriglitazone, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone can be used in the study of neuroinflammatory and neurodegenerative diseases.
    Leriglitazone-d4
  • HY-118167R
    Monoethylglycinexylidide (Standard) 7728-40-7
    Monoethylglycinexylidide (Standard) is the analytical standard of Monoethylglycinexylidide. This product is intended for research and analytical applications. Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver.
    Monoethylglycinexylidide (Standard)
  • HY-118861B
    Enclomiphene hydrochloride 14158-65-7 98%
    Enclomiphene ((E)-Clomiphene) hydrochloride is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene hydrochloride can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.
    Enclomiphene hydrochloride
  • HY-119222A
    GSK256073 tris 1228650-42-7 98%
    GSK256073 tris is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 tris acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia. GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
    GSK256073 tris
  • HY-119395A
    Kynuramine dihydrobromide 304-47-2 98%
    Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase.
    Kynuramine dihydrobromide
  • HY-119532R
    Nordeprenyl (Standard) 18913-84-3
    Chromium picolinate (Standard) is the analytical standard of Chromium picolinate. This product is intended for research and analytical applications. Chromium picolinate (Chromium (III) picolinate) is a compound that has oral activity. Chromium picolinate induces apoptosis. Chromium picolinate is the activator of p38 MAPK. Chromium picolinate has antioxidant activity. Chromium picolinate can be used in research on type 2 diabetes.
    Nordeprenyl (Standard)
  • HY-120160A
    Darglitazone Sodium 149904-87-0 98%
    Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research.
    Darglitazone Sodium
  • HY-120643A
    BMS-823778 1140897-32-0 98%
    BMS-823778 was developed as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 to inhibit type 2 diabetes.
    BMS-823778
  • HY-121161C
    (2R,3S)-Brassinazole 259200-30-1 99.83%
    Brassinazole (0.5, 1, 5 μM) causes markedly deformed seedlings, whose morphology is similar to that of BR-deficient mutants. Brassinazole causes cress dwarfism, altering leaf morphology such as the typical downward curl and dark green appearance of Arabidopsis BR-deficient mutants. However, administration of 10 nM BR reversed dwarfism.
    (2R,3S)-Brassinazole
  • HY-121212R
    Icosabutate (Standard) 1253909-57-7
    Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant.
    Icosabutate (Standard)
  • HY-121238R
    Hyocholic Acid (Standard) 547-75-1
    Hyocholic Acid (Standard) is the analytical standard of Hyocholic Acid. This product is intended for research and analytical applications. Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].
    Hyocholic Acid (Standard)
  • HY-121447R
    Heneicosanoic acid (Standard) 2363-71-5
    Heneicosanoic acid (Standard) is the analytical standard of Heneicosanoic acid. This product is intended for research and analytical applications. Heneicosanoic acid is a long-chain saturated fatty acid which is found in plants and animals.
    Heneicosanoic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity